Blar i forfatter "Kee, Frank"

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    • Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes 

      Csengeri, Dora; Sprünker, Ngoc-Anh; Di Castelnuovo, Augusto F; Niiranen, Teemu; Vishram-Nielsen, Julie K.K.; Costanzo, Simona; Soderberg, Stefan; Jensen, Steen M; Vartiainen, Erkki; Donati, Maria Benedetta; Magnussen, Christina; Camen, Stephan; Gianfagna, Francesco; Løchen, Maja-Lisa; Kee, Frank; Kontto, Jukka; Mathiesen, Ellisiv B.; Koenig, Wolfgang; Blankenberg, Stefan; de Gaetano, Giovanni; Jørgensen, Torben; Kuulasmaa, Kari; Zeller, Tanja; Salomaa, Veikko; Iacoviello, Licia; Schnabel, Renate B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-13)
      Aims<p> <p>There is inconsistent evidence on the relation of alcohol intake with incident atrial fibrillation (AF), in particular at lower doses. We assessed the association between alcohol consumption, biomarkers, and incident AF across the spectrum of alcohol intake in European cohorts.<p> <p>Methods and results <p> In a community-based pooled cohort, we followed 107 845 individuals for the ...

    • Alcohol intake and total mortality in 142 960 individuals from the MORGAM Project: a population-based study 

      Di Castelnuovo, Augusto; Costanzo, Simona; Bonaccio, Marialaura; McElduff, Patrick; Salomaa, Veikko; Männistö, Satu; Moitry, Marie; Ferrières, Jean; Dallongeville, Jean; Thorand, Barbara; Brenner, Hermann; Ferrario, Marco; Veronesi, Giovanni; Pettenuzzo, Emanuela; Tamosiunas, Abdonas; Njølstad, Inger; Drygas, Wojciech; Nikitin, Yuri; Söderberg, Stefan; Kee, Frank; Grassi, Guido; Westermann, Dirk; Schrage, Benedikt; Dabboura, Salim; Zeller, Tanja; Kuulasmaa, Kari; Blankenberg, Stefan; Donati, Maria Benedetta; de Gaetano, Giovanni; Iacoviello, Licia (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-09)
      Aim To test the association of alcohol consumption with total and cause-specific mortality risk. Design Prospective observational multi-centre population-based study. Setting Sixteen cohorts (15 from Europe) in the MOnica Risk, Genetics, Archiving and Monograph (MORGAM) Project. Participants A total of 142 960 individuals (mean age 50 ± 13 years, 53.9% men). Measurements Average alcohol intake by ...

    • Application of non-HDL cholesterol for population-based cardiovascular risk stratification: results from the Multinational Cardiovascular Risk Consortium 

      Brunner, Fabian J.; Waldeyer, Christoph; Ojeda, Francisco; Salomaa, Veikko; Kee, Frank; Sans, Susana; Thorand, Barbara; Giampaoli, Simona; Brambilla, Paolo; Tunstall-Pedoe, Hugh; Moitry, Marie; Iacoviello, Licia; Veronesi, Giovanni; Grassi, Guido; Mathiesen, Ellisiv B.; Söderberg, Stefan; Linneberg, Allan; Brenner, Hermann; Amouyel, Philippe; Ferrières, Jean; Tamosiunas, Abdonas; Nikitin, Yuriy P.; Drygas, Wojciech; Melander, Olle; Jöckel, Karl-Heinz; Leistner, David M.; Shaw, Jonathan E.; Panagiotakos, Demosthenes B.; Simons, Leon A.; Kavousi, Maryam; Vasan, Ramachandran S.; Dullaart, Robin P.F.; Wannamethee, S. Goya; Risérus, Ulf; Shea, Steven; de Lemos, James A.; Omland, Torbjørn; Kuulasmaa, Kari; Landmesser, Ulf; Blankenberg, Stefan (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-03)
      <i>Background</i> - The relevance of blood lipid concentrations to long-term incidence of cardiovascular disease and the relevance of lipid-lowering therapy for cardiovascular disease outcomes is unclear. We investigated the cardiovascular disease risk associated with the full spectrum of bloodstream non-HDL cholesterol concentrations. We also created an easy-to-use tool to estimate the long-term ...

    • Association of iron deficiency with incident cardiovascular diseases and mortality in the general population 

      Schrage, Benedict; Rübsamen, Nicole; Ojeda, Francisco; Thorand, Barbara; Peters, Annette; Koenig, Wolfgang; Söderberg, Stefan; Söderberg, Maja; Mathiesen, Ellisiv B.; Njølstad, Inger; Kee, Frank; Linneberg, Allan; Kuulasmaa, Kari; Palosaari, Tarja; Salomaa, Veikko; Blankenberg, Stefan; Zeller, Tanja; Karakas, Mahir (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-05)
      Aims - Although absolute (AID) and functional iron deficiency (FID) are known risk factors for patients with cardiovascular (CV) disease, their relevance for the general population is unknown. The aim was to assess the association between AID/FID with incident CV disease and mortality in the general population.<p> <p>Methods and results - In 12 164 individuals from three European population-based ...

    • Combined Influence of Waist and Hip Circumference on Risk of Death in a Large Cohort of European and Australian Adults 

      Cameron, Adrian J.; Romaniuk, Helena; Orellana, Liliana; Dallongeville, Jean; Dobson, Annette J; Drygas, Wojciech; Ferrario, Marco; Ferrieres, Jean; Giampaoli, Simona; Gianfagna, Francesco; Iacoviello, Licia; Jousilahti, Pekka; Kee, Frank; Moitry, Marie; Niiranen, Teemu J; Pajak, Andrzej; Palmieri, Luigi; Palosaari, Tarja; Mannisto, Satu; Tamosiunas, Abdonas; Thorand, Barbara; Toft, Ulla; Vanuzzo, Diego; Salomaa, Veikko; Veronesi, Giovanni; Wilsgaard, Tom; Kuulasmaa, Kari; Söderberg, Stefan (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-30)
      Background - Waist circumference and hip circumference are both strongly associated with risk of death; however, their joint association has rarely been investigated.<p> <p>Methods and Results - The MONICA Risk, Genetics, Archiving, and Monograph (MORGAM) Project was conducted in 30 cohorts from 11 countries; 90 487 men and women, aged 30 to 74 years, predominantly white, with no history of ...

    • Comparison of general obesity and measures of body fat distribution in older adults in relation to cancer risk: Meta-analysis of individual participant data of seven prospective cohorts in Europe 

      Freisling, Heinz; Arnold, Melina; Soerjomataram, Isabelle; O'Doherty, Mark George; Ordóñez-Mena, José Manuel; Bamia, Christina; Kampman, Ellen; Leitzmann, Michael; Romieu, Isabelle; Kee, Frank; Tsilidis, Konstantinos; Tjønneland, Anne; Trichopoulou, Antonia; Boffetta, Paolo; Benetou, Vassiliki; Bueno-De-Mesquita, Hendrik Bastiaan; Huerta, José María; Brenner, Hermann; Wilsgaard, Tom; Jenab, Mazda (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-25)

    • Effect of major lifestyle risk factors, independent and jointly, on life expectancy with and without cardiovascular disease: results from the Consortium on Health and Ageing Network of Cohorts in Europe and the United States (CHANCES) 

      O'Doherty, Mark G.; Cairns, Karen; O'Neill, Vikki; Lamrock, Felicity; Jørgensen, Torben; Brenner, Hermann; Schöttker, Ben; Wilsgaard, Tom; Siganos, Galatios; Kuulasmaa, Kari; Boffetta, Paolo; Trichopoulou, Antonia; Kee, Frank (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-01-18)
      Seldom have studies taken account of changes in lifestyle habits in the elderly, or investigated their impact on disease-free life expectancy (LE) and LE with cardiovascular disease (CVD). Using data on subjects aged 50+ years from three European cohorts (RCPH, ESTHER and Tromsø), we used multi-state Markov models to calculate the independent and joint effects of smoking, physical activity, obesity ...

    • Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality. 

      Magnussen, Christina; Ojeda, Francisco M.; Leong, Darryl P.; Alegre-Diaz, Jesus; Amouyel, Philippe; Aviles-Santa, Larissa; De Bacquer, Dirk; Ballantyne, Christie M.; Bernabé-Ortiz, Antonio; Bobak, Martin; Brenner, Hermann; Carrillo-Larco, Rodrigo M.; De Lemos, James; Dobson, Annette; Dörr, Marcus; Donfrancesco, Chiara; Drygas, Wojciech; Dullaart, Robin P.; Engström, Gunnar; Ferrario, Marco M.; Ferrières, Jean; De Gaetano, Giovanni; Goldbourt, Uri; Gonzalez, Clicerio; Grassi, Guido; Hodge, Allison M.; Hveem, Kristian; Iacoviello, Licia; Ikram, M. Kamran; Irazola, Vilma; Jobe, Modou; Jousilahti, Pekka; Kaleebu, Pontiano; Kavousi, Maryam; Kee, Frank; Khalili, Davood; Koenig, Wolfgang; Kontsevaya, Anna; Kuulasmaa, Kari; Lackner, Karl J.; Leistner, David M.; Lind, Lars; Linneberg, Allan; Lorenz, Thiess; Lyngbakken, Magnus Nakrem; Malekzadeh, Reza; Malyutina, Sofia; Mathiesen, Ellisiv B.; Melander, Olle; Metspalu, Andres; Miranda, J. Jaime; Moitry, Marie; Mugisha, Joseph; Nalini, Mahdi; Nambi, Vijay; Ninomiya, Toshiharu; Oppermann, Karen; D'Orsi, Eleonora; Pająk, Andrzej; Palmieri, Luigi; Panagiotakos, Demosthenes; Perianayagam, Arokiasamy; Peters, Annette; Poustchi, Hossein; Prentice, Andrew M.; Prescott, Eva; Risérus, Ulf; Salomaa, Veikko; Sans, Susana; Sakata, Satoko; Schöttker, Ben; Schutte, Aletta E.; Sepanlou, Sadaf G.; Sharma, Sanjib Kumar; Shaw, Jonathan E.; Simons, Leon A.; Söderberg, Stefan; Tamosiunas, Abdonas; Thorand, Barbara; Tunstall-Pedoe, Hugh; Twerenbold, Raphael; Vanuzzo, Diego; Veronesi, Giovanni; Waibel, Julia; Wannamethee, S. Goya; Watanabe, Masafumi; Wild, Philipp S.; Yao, Yao; Zeng, Yi; Ziegler, Andreas; Blankenberg, Stefan (Journal article; Tidsskriftartikkel; Peer reviewed, 2023)
      BACKGROUND - Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and their effect on these outcomes are lacking.<p> <p>METHODS - We pooled and harmonized individual-level data from 112 cohort studies conducted in 34 countries and 8 geographic ...

    • HbA1c levels in non-diabetic older adults - No J-shaped associations with primary cardiovascular events, cardiovascular and all-cause mortality after adjustment for confoundersin a meta-analysis of individual participant data from six cohort studies 

      Schöttker, Ben; Rathmann, Wolfgang; Herder, Christian; Thorand, Barbara; Wilsgaard, Tom; Njølstad, Inger; Siganos, Galatios; Mathiesen, Ellisiv B.; Saum, Kai-Uwe; Peasey, Anne; Feskens, Edith J.M.; Boffetta, Paolo; Trichopoulou, Antonia; Kuulasmaa, Kari; Kee, Frank; Brenner, Hermann (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-02-11)
      Background:<br>To determine the shape of the associations of HbA1c with mortality and cardiovascular outcomes in non-diabetic individuals and explore potential explanations.<br> Methods:<br> The associations of HbA1c with all-cause mortality, cardiovascular mortality and primary cardiovascular events (myocardial infarction or stroke) were assessed in non-diabetic subjects ≥50 years from six ...

    • Impact of smoking and smoking cessation on cardiovascular events and mortality among older adults: Meta-analysis of Individual participant data from prospective cohort studies of the CHANCES consortium 

      Mons, Ute; Muezzinler, Aysel; Gellert, Carolin; Schöttker, Ben; Abnet, Christian C.; Bobak, Martin; de Groot, Lisette; Freedman, Neal D.; Jansen, Eugène; Kee, Frank; Kromhout, Daan; Kuulasmaa, Kari; Laatikainen, Tiina; O’Doherty, Mark G.; Bueno-de-Mesquita, H. Bas; Orfanos, Philippos; Peters, Annette; van der Schouw, Yvonne T.; Wilsgaard, Tom; Wolk, Alicja; Trichopoulou, Antonia; Boffetta, Paolo; Brenner, Hermann (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-04-20)
      Objective To investigate the impact of smoking and smoking cessation on cardiovascular mortality, acute coronary events, and stroke events in people aged 60 and older, and to calculate and report risk advancement periods for cardiovascular mortality in addition to traditional epidemiological relative risk measures.<p> <p>Design Individual participant meta-analysis using data from 25 cohorts ...

    • Quantification of the smoking-associated cancer risk with rate advancement periods: Meta-analysis of individual participant data from cohorts of the CHANCES consortium 

      Ordóñez-Mena, José Manuel; Schöttker, Ben; Mons, Ute; Jenab, Mazda; Freisling, Heinz; Bueno-De-Mesquita, Hendrik Bastiaan; O'Doherty, Mark G.; Scott, Angela; Kee, Frank; Stricker, Bruno H.; Hofman, Albert; de Keyser, Catherine E.; Ruiter, Rikje; Söderberg, Stefan; Jousilahti, Pekka; Kuulasmaa, Kari; Freedman, Neal D.; Wilsgaard, Tom; de Groot, Lisette C.P.G.M.; Kampman, Ellen; Håkansson, Niclas; Orsini, Nicola; Wolk, Alicja; Nilsson, Lena Maria; Tjønneland, Anne; Pająk, Andrzej; Malyutina, Sofia; Kúbinová, Růžena; Tamosiunas, Abdonas; Bobak, Martin; Katsoulis, Michail; Orfanos, Philippos; Boffetta, Paolo; Trichopoulou, Antonia; Brenner, Hermann (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-04-05)
      Background:<br> Smoking is the most important individual risk factor for many cancer sites but its association with breast and prostate cancer is not entirely clear. Rate advancement periods (RAPs) may enhance communication of smoking related risk to the general population. Thus, we estimated RAPs for the association of smoking exposure (smoking status, time since smoking cessation, smoking ...

    • Risk Factors, Subsequent Disease Onset, and Prognostic Impact of Myocardial Infarction and Atrial Fibrillation 

      Camen, Stephan; Csengeri, Dora; Geelhoed, Bastiaan; Niiranen, Teemu; Gianfagna, Francesco; Vishram-Nielsen, Julie K.; Costanzo, Simona; Söderberg, Stefan; Vartiainen, Erkki; Börschel, Christin S.; Donati, Maria Benedetta; Løchen, Maja-Lisa; Ojeda, Francisco M.; Kontto, Jukka; Mathiesen, Ellisiv B.; Jensen, Steen; Koenig, Wolfgang; Kee, Frank; de Gaetano, Giovanni; Zeller, Tanja; Jørgensen, Torben; Tunstall-Pedoe, Hugh; Blankenberg, Stefan; Kuulasmaa, Kari; Linneberg, Allan; Salomaa, Veikko; Iacoviello, Licia; Schnabel, Renate B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-24)
      BACKGROUND: Although myocardial infarction (MI) and atrial fibrillation (AF) are frequent comorbidities and share common cardiovascular risk factors, the direction and strength of the association of the risk factors with disease onset, subsequent disease incidence, and mortality are not completely understood.<p> <p>METHODS AND RESULTS: In pooled multivariable Cox regression analyses, we examined ...

    • A saturated map of common genetic variants associated with human height 

      Yengo, Loïc; Vedantam, Sailaja; Marouli, Eirini; Sidorenko, Julia; Bartell, Eric; Sakaue, Saori; Graff, Marielisa; Eliasen, Anders U.; Jiang, Yunxuan; Raghavan, Sridharan; Miao, Jenkai; Arias, Joshua D.; Graham, Sarah E.; Mukamel, Ronen E.; Spracklen, Cassandra N.; Yin, Xianyong; Chen, Shyh-Huei; Ferreira, Teresa; Highland, Heather H.; Ji, Yingjie; Karaderi, Tugce; Lin, Kuang; Lüll, Kreete; Malden, Deborah E.; Medina-Gomez, Carolina; Machado, Moara; Moore, Amy; Rüeger, Sina; Sim, Xueling; Vrieze, Scott; Ahluwalia, Tarunveer S.; Akiyama, Masato; Allison, Matthew A.; Alvarez, Marcus; Andersen, Mette K.; Ani, Alireza; Appadurai, Vivek; Arbeeva, Liubov; Bhaskar, Seema; Bielak, Lawrence F.; Bollepalli, Sailalitha; Bonnycastle, Lori L.; Bork-Jensen, Jette; Bradfield, Jonathan P.; Bradford, Yuki; Braund, Peter S.; Brody, Jennifer A.; Burgdorf, Kristoffer S.; Cade, Brian E.; Cai, Hui; Cai, Qiuyin; Campbell, Archie; Cañadas-Garre, Marisa; Catamo, Eulalia; Chai, Jin-Fang; Chai, Xiaoran; Chang, Li-Ching; Chang, Yi-Cheng; Chen, Chien-Hsiun; Chesi, Alessandra; Choi, Seung Hoan; Chung, Ren-Hua; Cocca, Massimiliano; Concas, Maria Pina; Couture, Christian; Cuellar-Partida, Gabriel; Danning, Rebecca; Daw, E. Warwick; Degenhard, Frauke; Delgado, Graciela E.; Delitala, Alessandro; Demirkan, Ayse; Deng, Xuan; Devineni, Poornima; Dietl, Alexander; Dimitriou, Maria; Dimitrov, Latchezar; Dorajoo, Rajkumar; Ekici, Arif B.; Engmann, Jorgen E.; Fairhurst-Hunter, Zammy; Farmaki, Aliki-Eleni; Faul, Jessica D.; Fernandez-Lopez, Juan-Carlos; Forer, Lukas; Francescatto, Margherita; Freitag-Wolf, Sandra; Fuchsberger, Christian; Galesloot, Tessel E.; Gao, Yan; Gao, Zishan; Geller, Frank; Giannakopoulou, Olga; Giulianini, Franco; Gjesing, Anette P.; Goel, Anuj; Gordon, Scott D.; Gorski, Mathias; Grove, Jakob; Guo, Xiuqing; Gustafsson, Stefan; Haessler, Jeffrey; Hansen, Thomas; Havulinna, Aki S.; Haworth, Simon J.; He, Jing; Heard-Costa, Nancy; Hebbar, Prashantha; Hindy, George; Ho, Yuk-Lam A.; Hofer, Edith; Holliday, Elizabeth; Horn, Katrin; Hornsby, Whitney E.; Hottenga, Jouke-Jan; Huang, Hongyan; Huang, Jie; Huerta-Chagoya, Alicia; Huffman, Jennifer E.; Hung, Yi-Jen; Huo, Shaofeng; Hwang, Mi Yeong; Iha, Hiroyuki; Ikeda, Daisuke D.; Isono, Masato; Jackson, Anne U.; Jäger, Susanne; Jansen, Iris E.; Johansson, Ingegerd; Jonas, Jost B.; Jonsson, Anna; Jørgensen, Torben; Kalafati, Ioanna-Panagiota; Kanai, Masahiro; Kanoni, Stavroula; Kårhus, Line L.; Kasturiratne, Anuradhani; Katsuya, Tomohiro; Kawaguchi, Takahisa; Kember, Rachel L.; Kentistou, Katherine A.; Kim, Han-Na; Kim, Young Jin; Kleber, Marcus E.; Knol, Maria J.; Kurbasic, Azra; Lauzon, Marie; Le, Phuong; Lea, Rodney; Lee, Jong-Young; Leonard, Hampton L.; Li, Shengchao A.; Li, Xiaohui; Li, Xiaoyin; Liang, Jingjing; Lin, Honghuang; Lin, Shih-Yi; Liu, Jun; Liu, Xueping; Lo, Ken Sin; Long, Jirong; Lores-Motta, Laura; Luan, Jian’an; Lyssenko, Valeriya; Lyytikäinen, Leo-Pekka; Mahajan, Anubha; Mamakou, Vasiliki; Mangino, Massimo; Manichaikul, Ani; Marten, Jonathan; Mattheisen, Manuel; Mavarani, Laven; McDaid, Aaron F.; Meidtner, Karina; Melendez, Tori L.; Mercader, Josep M.; Milaneschi, Yuri; Miller, Jason E.; Millwood, Iona Y.; Mishra, Pashupati P.; Mitchell, Ruth E.; Møllehave, Line T.; Morgan, Anna; Mucha, Soeren; Munz, Matthias; Nakatochi, Masahiro; Nelson, Christopher P.; Nethander, Maria; Nho, Chu Won; Nielsen, Aneta A.; Nolte, Ilja M.; Nongmaithem, Suraj S.; Noordam, Raymond; Ntalla, Ioanna; Nutile, Teresa; Pandit, Anita; Christofidou, Paraskevi; Pärna, Katri; Pauper, Marc; Petersen, Eva R. B.; Petersen, Liselotte V.; Pitkänen, Niina; Polašek, Ozren; Poveda, Alaitz; Preuss, Michael H.; Pyarajan, Saiju; Raffield, Laura M.; Rakugi, Hiromi; Ramirez, Julia; Rasheed, Asif; Raven, Dennis; Rayner, Nigel W.; Riveros, Carlos; Rohde, Rebecca; Ruggiero, Daniela; Ruotsalainen, Sanni E.; Ryan, Kathleen A.; Sabater-Lleal, Maria; Saxena, Richa; Scholz, Markus; Sendamarai, Anoop; Shen, Botong; Shi, Jingchunzi; Shin, Jae Hun; Sidore, Carlo; Sitlani, Colleen M.; Slieker, Roderick C.; Smit, Roelof A. J.; Smith, Albert V.; Smith, Jennifer A.; Smyth, Laura J.; Southam, Lorraine; Steinthorsdottir, Valgerdur; Sun, Liang; Takeuchi, Fumihiko; Tallapragada, Divya Sri Priyanka; Taylor, Kent D.; Tayo, Bamidele O.; Tcheandjieu, Catherine; Terzikhan, Natalie; Tesolin, Paola; Teumer, Alexander; Theusch, Elizabeth; Thompson, Deborah J.; Thorleifsson, Gudmar; Timmers, Paul R. H. J.; Trompet, Stella; Turman, Constance; Vaccargiu, Simona; van der Laan, Sander W.; van der Most, Peter J.; van Klinken, Jan B.; van Setten, Jessica; Verma, Shefali S.; Verweij, Niek; Veturi, Yogasudha; Wang, Carol A.; Wang, Chaolong; Wang, Lihua; Wang, Zhe; Warren, Helen R.; Bin Wei, Wen; Wickremasinghe, Ananda R.; Wielscher, Matthias; Wiggins, Kerri L.; Winsvold, Bendik K S; Wong, Andrew; Wu, Yang; Wuttke, Matthias; Xia, Rui; Xie, Tian; Yamamoto, Ken; Yang, Jingyun; Yao, Jie; Young, Hannah; Yousri, Noha A.; Yu, Lei; Zeng, Lingyao; Zhang, Weihua; Zhang, Xinyuan; Zhao, Jing-Hua; Zhao, Wei; Zhou, Wei; Zimmermann, Martina E.; Zoledziewska, Magdalena; Adair, Linda S.; Adams, Hieab H. H.; Aguilar-Salinas, Carlos A.; Al-Mulla, Fahd; Arnett, Donna K.; Asselbergs, Folkert W.; Åsvold, Bjørn Olav; Attia, John; Banas, Bernhard; Bandinelli, Stefania; Bennett, David A.; Bergler, Tobias; Bharadwaj, Dwaipayan; Biino, Ginevra; Bisgaard, Hans; Boerwinkle, Eric; Böger, Carsten A.; Bønnelykke, Klaus; Boomsma, Dorret I.; Børglum, Anders D.; Borja, Judith B.; Bouchard, Claude; Bowden, Donald W.; Brandslund, Ivan; Brumpton, Ben Michael; Buring, Julie E.; Caulfield, Mark J.; Chambers, John C.; Chandak, Giriraj R.; Chanock, Stephen J.; Chaturvedi, Nish; Chen, Yii-Der Ida; Chen, Zhengming; Cheng, Ching-Yu; Christophersen, Ingrid E.; Ciullo, Marina; Cole, John W.; Collins, Francis S.; Cooper, Richard S.; Cruz, Miguel; Cucca, Francesco; Cupples, L. Adrienne; Cutler, Michael J.; Damrauer, Scott M.; Dantoft, Thomas M.; de Borst, Gert J.; de Groot, Lisette C. P. G. M.; De Jager, Philip L.; de Kleijn, Dominique P. V.; Janaka de Silva, de; Dedoussis, George V.; den Hollander, Anneke I.; Du, Shufa; Easton, Douglas F.; Elders, Petra J. M.; Eliassen, A. Heather; Ellinor, Patrick T.; Elmståhl, Sölve; Erdmann, Jeanette; Evans, Michele K.; Fatkin, Diane; Feenstra, Bjarke; Feitosa, Mary F.; Ferrucci, Luigi; Ford, Ian; Fornage, Myriam; Franke, Andre; Franks, Paul W.; Freedman, Barry I.; Gasparini, Paolo; Gieger, Christian; Girotto, Giorgia; Goddard, Michael E.; Golightly, Yvonne M.; Gonzalez-Villalpando, Clicerio; Gordon-Larsen, Penny; Grallert, Harald; Grant, Struan F. A.; Grarup, Niels; Griffiths, Lyn; Gudnason, Vilmundur; Haiman, Christopher; Hakonarson, Hakon; Hansen, Torben; Hartman, Catharina A.; Hattersley, Andrew T.; Hayward, Caroline; Heckbert, Susan R.; Heng, Chew-Kiat; Hengstenberg, Christian; Hewitt, Alex W.; Hishigaki, Haretsugu; Hoyng, Carel B.; Huang, Paul L.; Huang, Wei; Hunt, Steven C.; Hveem, Kristian; Hyppönen, Elina; Iacono, William G.; Ichihara, Sahoko; Ikram, M. Arfan; Isasi, Carmen R.; Jackson, Rebecca D.; Jarvelin, Marjo-Riitta; Jin, Zi-Bing; Jöckel, Karl-Heinz; Joshi, Peter K.; Jousilahti, Pekka; Jukema, J. Wouter; Kähönen, Mika; Kamatani, Yoichiro; Kang, Kui Dong; Kaprio, Jaakko; Kardia, Sharon L. R.; Karpe, Fredrik; Kato, Norihiro; Kee, Frank; Kessler, Thorsten; Khera, Amit V.; Khor, Chiea Chuen; Kiemeney, Lambertus A. L. M.; Kim, Bong-Jo; Kim, Eung Kweon; Kim, Hyung-Lae; Kirchhof, Paulus; Kivimaki, Mika; Koh, Woon-Puay; Koistinen, Heikki A.; Kolovou, Genovefa D.; Kooner, Jaspal S.; Kooperberg, Charles; Köttgen, Anna; Kovacs, Peter; Kraaijeveld, Adriaan; Kraft, Peter; Krauss, Ronald M.; Kumari, Meena; Kutalik, Zoltan; Laakso, Markku; Lange, Leslie A.; Langenberg, Claudia; Launer, Lenore J.; Le Marchand, Loic; Lee, Hyejin; Lee, Nanette R.; Lehtimäki, Terho; Li, Huaixing; Li, Liming; Lieb, Wolfgang; Lin, Xu; Lind, Lars; Linneberg, Allan; Liu, Ching-Ti; Liu, Jianjun; Loeffler, Markus; London, Barry; Lubitz, Steven A.; Lye, Stephen J.; Mackey, David A.; Mägi, Reedik; Magnusson, Patrik K. E.; Marcus, Gregory M.; Vidal, Pedro Marques; Martin, Nicholas G.; März, Winfried; Matsuda, Fumihiko; McGarrah, Robert W.; McGue, Matt; McKnight, Amy Jayne; Medland, Sarah E.; Mellström, Dan; Metspalu, Andres; Mitchell, Braxton D.; Mitchell, Paul; Mook-Kanamori, Dennis O.; Morris, Andrew D.; Mucci, Lorelei A.; Munroe, Patricia B.; Nalls, Mike A.; Nazarian, Saman; Nelson, Amanda E.; Neville, Matt J.; Newton-Cheh, Christopher; Nielsen, Christopher Sivert; Nöthen, Markus M.; Ohlsson, Claes; Oldehinkel, Albertine J.; Orozco, Lorena; Pahkala, Katja; Pajukanta, Päivi; Palmer, Colin N. A.; Parra, Esteban J.; Pattaro, Cristian; Pedersen, Oluf; Pennell, Craig E.; Penninx, Brenda W. J. H.; Perusse, Louis; Peters, Annette; Peyser, Patricia A.; Porteous, David J.; Posthuma, Danielle; Power, Chris; Pramstaller, Peter P.; Province, Michael A.; Qi, Qibin; Qu, Jia; Rader, Daniel J.; Raitakari, Olli T.; Ralhan, Sarju; Rallidis, Loukianos S.; Rao, Dabeeru C.; Redline, Susan; Reilly, Dermot F.; Reiner, Alexander P.; Rhee, Sang Youl; Ridker, Paul M.; Rienstra, Michiel; Ripatti, Samuli; Ritchie, Marylyn D.; Roden, Dan M.; Rosendaal, Frits Richard; Rotter, Jerome I.; Rudan, Igor; Rutters, Femke; Sabanayagam, Charumathi; Saleheen, Danish; Salomaa, Veikko; Samani, Nilesh J.; Sanghera, Dharambir K.; Sattar, Naveed; Schmidt, Börge; Schmidt, Helena; Schmidt, Reinhold; Schulze, Matthias B.; Schunkert, Heribert; Scott, Laura J.; Scott, Rodney J.; Sever, Peter; Shiroma, Eric J.; Shoemaker, M. Benjamin; Shu, Xiao-Ou; Simonsick, Eleanor M.; Sims, Mario; Singh, Jai Rup; Singleton, Andrew B.; Sinner, Moritz F.; Smith, J. Gustav; Snieder, Harold; Spector, Tim D.; Stampfer, Meir J.; Stark, Klaus J.; Strachan, David P.; ‘t Hart, Leen M.; Tabara, Yasuharu; Tang, Hua; Tardif, Jean-Claude; Thanaraj, Thangavel A.; Timpson, Nicholas J.; Tönjes, Anke; Tremblay, Angelo; Tuomi, Tiinamaija; Tuomilehto, Jaakko; Tusié-Luna, Maria-Teresa; Uitterlinden, Andre G.; van Dam, Rob M.; van der Harst, Pim; Van der Velde, Nathalie; van Duijn, Cornelia M.; van Schoor, Natasja M.; Vitart, Veronique; Völker, Uwe; Vollenweider, Peter; Völzke, Henry; Wacher-Rodarte, Niels H.; Walker, Mark; Wang, Ya Xing; Wareham, Nicholas J.; Watanabe, Richard M.; Watkins, Hugh; Weir, David R.; Werge, Thomas M.; Widen, Elisabeth; Wilkens, Lynne R.; Willemsen, Gonneke; Willett, Walter C.; Wilson, James F.; Wong, Tien-Yin; Woo, Jeong-Taek; Wright, Alan F.; Wu, Jer-Yuarn; Xu, Huichun; Yajnik, Chittaranjan S.; Yokota, Mitsuhiro; Yuan, Jian-Min; Zeggini, Eleftheria; Zemel, Babette S.; Zheng, Wei; Zhu, Xiaofeng; Zmuda, Joseph M.; Zonderman, Alan B.; Zwart, John Anker Henrik; Partida, Gabriel Cuellar; Sun, Yan; Croteau-Chonka, Damien; Vonk, Judith M.; Chanock, Stephen; Chasman, Daniel I.; Cho, Yoon Shin; Heid, Iris M.; McCarthy, Mark I.; Ng, Maggie C. Y.; O’Donnell, Christopher J.; Rivadeneira, Fernando; Thorsteinsdottir, Unnur; Sun, Yan V.; Tai, E. Shyong; Boehnke, Michael; Deloukas, Panos; Justice, Anne E.; Lindgren, Cecilia M.; Loos, Ruth J. F.; Mohlke, Karen L.; North, Kari E.; Stefansson, Kari; Walters, Robin G.; Winkler, Thomas W.; Young, Kristin L.; Loh, Po-Ru; Yang, Jian; Esko, Tõnu; Assimes, Themistocles L.; Auton, Adam; Abecasis, Goncalo R.; Willer, Cristen J.; Locke, Adam E.; Berndt, Sonja I.; Lettre, Guillaume; Frayling, Timothy M.; Okada, Yukinori; Wood, Andrew R.; Hirschhorn, Joel N. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-12)
      Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50% of phenotypic variation in human height, but identifying the specifc variants and associated regions requires huge sample sizes1 . Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are signifcantly associated ...

    • Simple cardiovascular risk stratification by replacing total serum cholesterol with anthropometric measures: The MORGAM prospective cohort project 

      Rosberg, Victoria; Vishram-Nielsen, Julie KK; Kristensen, Anna M. Dyrvig; Pareek, Manan; Sehested, Thomas S.G.; Nilsson, Peter M; Linneberg, Allan; Palmieri, Luigi; Giampaoli, Simona; Donfrancesco, Chiara; Kee, Frank; Mancia, Giuseppe; Cesana, Giancarlo; Veronesi, Giovanni; Grassi, Guido; Kuulasmaa, Kari; Salomaa, Veikko; Palosaari, Tarja; Sans, Susana; Ferrieres, Jean; Dallongeville, Jean; Söderberg, Stefan; Moitry, Marie; Drygas, Wojciech; Tamosiunas, Abdonas; Peters, Annette; Brenner, Hermann; Schöttker, Ben; Grimsgaard, Sameline; Biering-Sørensen, Tor; Olsen, Michael H (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-27)
      To assess whether anthropometric measures (body mass index [BMI], waist-hip ratio [WHR], and estimated fat mass [EFM]) are independently associated with major adverse cardiovascular events (MACE), and to assess their added prognostic value compared with serum total-cholesterol. The study population comprised 109,509 individuals (53% men) from the MORGAM-Project, aged 19–97 years, without established ...

    • Socioeconomic position, lifestyle habits and biomarkers of epigenetic aging: A multi-cohort analysis 

      Fiorito, Giovanni; McCrory, Cathal; Robinson, Oliver; Carmeli, Cristian; Rosales, Carolina Ochoa; Zhang, Yan; Colicino, Elena; Dugué, Pierre-Antoine; Artaud, Fanny; McKay, Gareth J.; Jeong, Ayoung; Mishra, Pashupati P.; Nøst, Therese Haugdahl; Krogh, Vittorio; Panico, Salvatore; Sacerdote, Carlotta; Tumino, Rosario; Palli, Domenico; Matullo, Giuseppe; Guarrera, Simonetta; Gandini, Martina; Bochud, Murielle; Dermitzakis, Emmanouil; Muka, Taulant; Schwartz, Joel; Vokonas, Pantel S.; Just, Allan; Hodge, Allison M.; Giles, Graham G.; Southey, Melissa C.; Hurme, Mikko A.; Young, Ian; McKnight, Amy Jayne; Kunze, Sonja; Waldenberger, Melanie; Peters, Annette; Schwettmann, Lars; Lund, Eiliv; Baccarelli, Andrea; Milne, Roger L.; Kenny, Rose A.; Elbaz, Alexis; Brenner, Hermann; Kee, Frank; Voortman, Trudy; Probst-Hensch, Nicole; Lehtimäki, Terho; Elliot, Paul; Stringhini, Silvia; Vineis, Paolo; Polidoro, Silvia (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-14)
      <p>Differences in health status by socioeconomic position (SEP) tend to be more evident at older ages, suggesting the involvement of a biological mechanism responsive to the accumulation of deleterious exposures across the lifespan. DNA methylation (DNAm) has been proposed as a biomarker of biological aging that conserves memory of endogenous and exogenous stress during life. <p>We examined the ...